Yao-An Shen, PhD
Associate Professor
Department of Pathology/ Graduate Institute of Clinical Medicine/
International Master/Ph.D. Program in Medicine, College of Medicine, Taipei
Medical University, Taipei 110301, Taiwan
Email: shen1202@tmu.edu.tw
Education
- 2009-2015 Ph.D., Institute of Biochemistry and Molecular Biology, National Yang Ming University
- 2007-2009 M.S., Department of Life Sciences and Institute of Genome Sciences, National Yang Ming University
- 2000-2004 B.S., Department of Life Science, Tzu Chi University
Experience
- 2024.02- Associate Professor, Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University
- 2024.02- Joint-Appointment Associate Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 2020.02-2024.02 Assistant Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 2019.06-2024.02 Assistant Professor, Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University
- 2016.08-2019.06 Postdoctoral Research Fellow, Johns Hopkins University
- 2015.08-2016.08 Postdoctoral Research Fellow, National Yang-Ming University
- 2015.02-2015.07 Postdoctoral Research Fellow, Taipei Veterans General Hospital
Professional Specialty
- Translational Research – Investigation of small molecule inhibitors targeting GLS and PBX1 as cancer therapeutics
- Cell Therapy – Therapeutic application of stem cells for regenerative medicine and immune cells for anti-cancer therapy
- Cancer Metabolism – Investigation of metabolic compensation and microenvironmental landscape of therapeutic resistant cells
- Cancer Stem Cell Research – Investigation of the molecular mechanism of metabolic reprogramming of cancer stem cell and biomarker discovery for targeted therapy
- Induced Pluripotent Stem Cell Research – Interrogation of metabolic reprogramming and anti-cancer applications of induced pluripotent stem cells
- Nanomedicine – Investigation of targeted delivery systems of nanobiomaterials for cancer stem cell treatment
Teaching Subjects
General Biology, General Chemistry, Biochemistry and Molecular Biology, Molecular Pathology, Genetics, Bioenergetics and Metabolism, Cancer Stem Cell Biology, Stem Cell Biology, Translational Medicine, Development of Cancer Therapeutic, Problem-Based Learning, Critical Thinking and Research Design
Grants and Awards
- 2025.01.01-2029.12.31 PI – Development of Acid-Responsive Mesoporous Silica Nanoparticles for Delivery of PBX1 Inhibitors Targeting Cancer Stem Cell Transcriptional Activity (National Health Research Institutes provided the total budget of $15,000,000)
- 2024.08.01 Elected a full member of Sigma Xi, the Scientific Research Honor Society
- 2024.08.01-2028.07.31 PI – Utilizing Glucosamine-Labeled Nanodrugs as a Novel Pancreatic Cancer Stem Cell Therapy to Counteract Metabolic Compensation and Synergistically Inhibit Transcriptional Activity (National Science and Technology Council provided the total budget of $40,000,000)
- 2024.10.01-2025.09.30 PI – Development of Prodrugs and Dual Target Drugs of PBX1 Transcription Factor Small Molecule Inhibitor (National Science and Technology Council provided the total budget of $5,000,000)
- 2024.01.01-2024.12.31 PI – Commercial Applications of Technique Platform Development for Cancer Stem Cell Isolation and Cell Therapy (National Science and Technology Council provided the total budget of $7,450,000)
- 2023.08.01-2024.07.31 PI – Investigation on the synergistic effect of a combination of PCSK9 inhibitors and hyperthermia in hepatic cancer stem cells (National Science and Technology Council provided the total budget of $900,000) (NSTC 112-2314-B-038-081)
- 2023.05.05 Licensing & Technology Transfer – 8 Patents of Cell Expansion and Metabolic Selection Techniques (I CARE YOU Biotech provided a licensing fee of $3,000,000)
- 2023.01.01-2023.12.31 PI – Technique Platform Development for Cancer Stem Cell Isolation and Cell Therapy (Ministry of Science and Technology provided the total budget of $5,600,000) (NSTC 112-2823-8-038-001)
- 2022.08.01-2023.07.31 PI – Development of First-in-class Transcription Factor Drug Targeting Cancer Stem Cells (National Science and Technology Council provided the total budget of $1,000,000) (NSTC 111-2622-B-038-008)
- 2021.04.30-2022.04.30 Co-PI – Investigation of Hyperthermia Effects on Tumor Metabolism and Microenvironment in Radioresistant Bladder Cancer (Taipei Medical University Hospital provided the total budget of $700,000) (110TMU-TMUH-02-2)
- 2020.12.01-2023.11.30 PI – Investigation of Metabolic Isolation of Stem Cells and Its Effects on Differentiation Therapy of Cancer Stem Cells (I CARE YOU Biotech provided the total budget of $4,200,084) (A-109-084)
- 2020.02.01-2022.07.31 PI – Reversing Metabolic Compensation to Overcome Recurrence in Ovarian Cancer by Inhibition Of MYC/GLS Axis (Ministry of Science and Technology provided the total budget of $3,000,000) (MOST 109-2314-B-038 -021 -MY3)
- 2019.09.01 PI – Research Grants for Newly Hired Faculty (Taipei Medical University provided the total budget of $1,000,000) (TMU108-AE1-B12)
- 2016.11.28 Postdoctoral Research Abroad Program (PRAP) Award – Ministry of Science and Technology, Taiwan
- 2013.11.06 Young Investigator Award – International Symsposium on Mitochondria 2013 / The 13th Conference of Japanese Society of Mitochondrial Research and Medicine (J-mit), Japan
- 2013.11.04 Young Investigator Award – 10th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM), Korea
- 2013.10.19 First prize of Poster Award – 2013 Mini-symposium on Mitochondria and Aging, Taiwan
- 2013.10.16 Young Investigator Award – 6th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia), Taiwan
- 2013.09.07 Third Prize of Poster Award – 2013 International Symposium on Mitochondrial Dynamics in Translational Medicine, Taiwan
- 2012.11.02 Young Investigator Award – 2012 Conference of 9th ASMRM Beijing, China
- 2012.10.26 Silver Medal Award of Oral Session Competition – 7th International Symposium on Genomic Medicine of CCH, Taiwan
- 2011.10.07 Fellowships Award – 22nd FAOBMB Conference, Singapore
- 2011.08.31 Young Investigator Award – 2011 8th Conference of ASMRM in Kagoshima, Japan
- 2011.07.09 First prize of Poster Award – 2011 Mackay International Symposium on Mitochondrial Medicine in Human Health and Diseases in Taipei, Taiwan
- 2010.12.15 Young Investigator Award – 2010 7th Conference of ASMRM in Fukuoka, Japan
Academic Referees
- Ie-Ming Shih, MD, PhD. Richard W. TeLinde Professor, Departments of Pathology, Oncology, and Gynecology & Obstetrics, Johns Hopkins University School of Medicine. Tel: +1-410-502-7773 | E-mail: ishih@jhmi.edu
- Tian-Li Wang, PhD. Professor, Departments of Pathology, Oncology, and Gynecology & Obstetrics. Johns Hopkins University School of Medicine. Tel: +1-410-502-0863 | E-mail: tlw@jhmi.edu
- Chia-Ning Shen, PhD. Deputy Director of Administration, Genomics Research Center, Academia Sinica, Taipei, Taiwan. Tel: +886-2- 27891220 | E-mail: cnshen@gate.sinica.edu.tw
- Yau-Huei Wei, Ph.D. Distinguished Professor, Department of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan. Tel: +886-2-28267118 | E-mail: joeman@ym.edu.tw
- Chun-Liang Lo, Ph.D. Professor, Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan. Tel: +886-2-2826-7000 ext.7914 | E-mail: cllo@nycu.edu.tw
- Chi-Mu Chuang, M.D. Ph.D. Associate Professor, Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan Tel: +886-2-28757826 | E-mail: cmjuang@gmail.com
- Yann-Jang Chen, M.D. Ph.D. Associate Professor, Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan Tel: +886-2-28267032 | E-mail: yjchen0206@nycu.edu.tw